Comparative pharmacokinetics and safety assessment of transdermal berberine and dihydroberberine

The natural alkaloid berberine has been ascribed numerous health benefits including lipid and cholesterol reduction and improved insulin sensitivity in diabetics. However, oral (PO) administration of berberine is hindered by poor bioavailability and increasing dose often elicits gastro-intestinal si...

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Veröffentlicht in:PLoS One
Hauptverfasser: Buchanan, Beth, Meng, Qingfang, Poulin, Mathieu-Marc, Zuccolo, Jonathan, Azike, Chike Godwin, Gabriele, Joseph, Baranowski, David Charles
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5868852/
https://ncbi.nlm.nih.gov/pubmed/29579096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0194979
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