Comparative pharmacokinetics and safety assessment of transdermal berberine and dihydroberberine

The natural alkaloid berberine has been ascribed numerous health benefits including lipid and cholesterol reduction and improved insulin sensitivity in diabetics. However, oral (PO) administration of berberine is hindered by poor bioavailability and increasing dose often elicits gastro-intestinal si...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Buchanan, Beth, Meng, Qingfang, Poulin, Mathieu-Marc, Zuccolo, Jonathan, Azike, Chike Godwin, Gabriele, Joseph, Baranowski, David Charles
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5868852/
https://ncbi.nlm.nih.gov/pubmed/29579096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0194979
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