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Effects of berberine on pharmacokinetics of midazolam and rhodamine 123 in rats in vivo
AIM: To evaluate whether berberine hydrochloride (BBR) could modify the pharmacokinetic profiles of midazolam (MDZ), a substrate of CYP3A, and rhodamine 123 (Rh123), a substrate of P-glycolprotein (P-gp), in male rats. METHODS: The rats were given with varied does of BBR or 75 mg/kg ketoconazole as...
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| Publicado no: | Springerplus |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer International Publishing
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4811842/ https://ncbi.nlm.nih.gov/pubmed/27066387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40064-016-2013-z |
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