Effects of Schisandra sphenanthera extract on the pharmacokinetics of midazolam in healthy volunteers

AIMS: To assess the effect of Schisandra sphenanthera extract (SchE) on the pharmacokinetics of midazolam, a probe drug of CYP3A, and its metabolite 1′-hydroxy midazolam in healthy volunteers. METHODS: Twelve healthy male volunteers were orally treated with SchE, three capsules twice daily for 7 day...

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Detalhes bibliográficos
Main Authors: Xin, Hua-Wen, Wu, Xiao-Chun, Li, Qing, Yu, Ai-Rong, Xiong, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2009
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2686071/
https://ncbi.nlm.nih.gov/pubmed/19552749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03383.x
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