Transfer of rhodamine-123 into the brain and cerebrospinal fluid of fetal, neonatal and adult rats

BACKGROUND: Adenosine triphosphate binding cassette transporters such as P-glycoprotein (PGP) play an important role in drug pharmacokinetics by actively effluxing their substrates at barrier interfaces, including the blood-brain, blood-cerebrospinal fluid (CSF) and placental barriers. For a molecul...

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Bibliografiske detaljer
Udgivet i:Fluids Barriers CNS
Main Authors: Koehn, Liam M., Dziegielewska, Katarzyna M., Habgood, Mark D., Huang, Yifan, Saunders, Norman R.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7871379/
https://ncbi.nlm.nih.gov/pubmed/33557872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12987-021-00241-8
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