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Transfer of rhodamine-123 into the brain and cerebrospinal fluid of fetal, neonatal and adult rats
BACKGROUND: Adenosine triphosphate binding cassette transporters such as P-glycoprotein (PGP) play an important role in drug pharmacokinetics by actively effluxing their substrates at barrier interfaces, including the blood-brain, blood-cerebrospinal fluid (CSF) and placental barriers. For a molecul...
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| Veröffentlicht in: | Fluids Barriers CNS |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7871379/ https://ncbi.nlm.nih.gov/pubmed/33557872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12987-021-00241-8 |
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