Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule

[Image: see text] Human pancreatic ductal adenocarcinoma (PDAC) involves the dysregulation of multiple signaling pathways. A novel approach to the treatment of PDAC is described, involving the targeting of cancer genes in PDAC pathways having over-representation of G-quadruplexes, using the trisubst...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Med Chem
मुख्य लेखकों: Marchetti, Chiara, Zyner, Katherine G., Ohnmacht, Stephan A., Robson, Mathew, Haider, Shozeb M., Morton, Jennifer P., Marsico, Giovanni, Vo, Tam, Laughlin-Toth, Sarah, Ahmed, Ahmed A., Di Vita, Gloria, Pazitna, Ingrida, Gunaratnam, Mekala, Besser, Rachael J., Andrade, Ana C. G., Diocou, Seckou, Pike, Jeremy A., Tannahill, David, Pedley, R. Barbara, Evans, T. R. Jeffry, Wilson, W. David, Balasubramanian, Shankar, Neidle, Stephen
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Chemical Society 2018
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5867665/
https://ncbi.nlm.nih.gov/pubmed/29356532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01781
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