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Discovery of new G-quadruplex binding chemotypes
We report here on the discovery and preliminary evaluation of a novel non-macrocyclic low molecular weight quadruplex-stabilizing chemotype. The lead compounds, based on a furan core, show high G-quadruplex stabilisation and selectivity as well as potent in vitro anti-proliferative activity.
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3901018/ https://ncbi.nlm.nih.gov/pubmed/24302123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cc48616h |
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