Discovery of new G-quadruplex binding chemotypes

Por Ohnmacht, Stephan A., Varavipour, Ehsan, Nanjunda, Rupesh, Pazitna, Ingrida, Di Vita, Gloria, Gunaratnam, Mekala, Kumar, Arvind, Ismail, Mohamed A., Boykin, David W., Wilson, W. David, Neidle, Stephen
Publicado em 2014

KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines

Por Lavrado, João, Brito, Hugo, Borralho, Pedro M., Ohnmacht, Stephan A., Kim, Nam-Soon, Leitão, Clara, Pisco, Sílvia, Gunaratnam, Mekala, Rodrigues, Cecília M. P., Moreira, Rui, Neidle, Stephen, Paulo, Alexandra
Publicado no Sci Rep (2015)

Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives

Por Brito, Hugo, Martins, Ana Cláudia, Lavrado, João, Mendes, Eduarda, Francisco, Ana Paula, Santos, Sofia A., Ohnmacht, Stephan A., Kim, Nam-Soon, Rodrigues, Cecília M. P., Moreira, Rui, Neidle, Stephen, Borralho, Pedro M., Paulo, Alexandra
Publicado no PLoS One (2015)

Synthesis and Initial in Vivo Studies with [(11)C]SB-216763: The First Radiolabeled Brain Penetrative Inhibitor of GSK-3

Por Li, Lei, Shao, Xia, Cole, Erin L., Ohnmacht, Stephan A., Ferrari, Valentina, Hong, Young T., Williamson, David J., Fryer, Tim D., Quesada, Carole A., Sherman, Phillip, Riss, Patrick J., Scott, Peter J. H., Aigbirhio, Franklin I.
Publicado no ACS Med Chem Lett (2015)

A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer

Por Ohnmacht, Stephan A, Marchetti, Chiara, Gunaratnam, Mekala, Besser, Rachael J, Haider, Shozeb M, Di Vita, Gloria, Lowe, Helen L, Mellinas-Gomez, Maria, Diocou, Seckou, Robson, Mathew, Šponer, Jiri, Islam, Barira, Barbara Pedley, R, Hartley, John A, Neidle, Stephen
Publicado no Sci Rep (2015)