Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives

BACKGROUND: A guanine-rich strand within the promoter of the KRAS gene can fold into an intra-molecular G-quadruplex structure (G4), which has an important role in the regulation of KRAS transcription. We have previously identified indolo[3,2-b]quinolines with a 7-carboxylate group and three alkylam...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Brito, Hugo, Martins, Ana Cláudia, Lavrado, João, Mendes, Eduarda, Francisco, Ana Paula, Santos, Sofia A., Ohnmacht, Stephan A., Kim, Nam-Soon, Rodrigues, Cecília M. P., Moreira, Rui, Neidle, Stephen, Borralho, Pedro M., Paulo, Alexandra
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449006/
https://ncbi.nlm.nih.gov/pubmed/26024321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126891
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