Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives.

A guanine-rich strand within the promoter of the KRAS gene can fold into an intra-molecular G-quadruplex structure (G4), which has an important role in the regulation of KRAS transcription. We have previously identified indolo[3,2-b]quinolines with a 7-carboxylate group and three alkylamine side cha...

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Detalhes bibliográficos
Main Authors: Hugo Brito, Ana Cláudia Martins, João Lavrado, Eduarda Mendes, Ana Paula Francisco, Sofia A Santos, Stephan A Ohnmacht, Nam-Soon Kim, Cecília M P Rodrigues, Rui Moreira, Stephen Neidle, Pedro M Borralho, Alexandra Paulo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2015-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC4449006?pdf=render
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