A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer

We report here that a tetra-substituted naphthalene-diimide derivative (MM41) has significant in vivo anti-tumour activity against the MIA PaCa-2 pancreatic cancer xenograft model. IV administration with a twice-weekly 15 mg/kg dose produces ca 80% tumour growth decrease in a group of tumour-bearing...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Sci Rep
Autores principales: Ohnmacht, Stephan A, Marchetti, Chiara, Gunaratnam, Mekala, Besser, Rachael J, Haider, Shozeb M, Di Vita, Gloria, Lowe, Helen L, Mellinas-Gomez, Maria, Diocou, Seckou, Robson, Mathew, Šponer, Jiri, Islam, Barira, Barbara Pedley, R, Hartley, John A, Neidle, Stephen
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468576/
https://ncbi.nlm.nih.gov/pubmed/26077929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11385
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares