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Targeting Human Gastrointestinal Stromal Tumour Cells with a Quadruplex-binding Small Molecule
The majority of human gastrointestinal stromal tumours (GIST) are driven by activating mutations in the proto-oncogene KIT, a tyrosine kinase receptor. Clinical treatment with imatinib targets the kinase domain of KIT, but tumour regrowth occurs as a result of the development of resistant mutations...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2900250/ https://ncbi.nlm.nih.gov/pubmed/19469547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900424a |
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