Targeting Human Gastrointestinal Stromal Tumour Cells with a Quadruplex-binding Small Molecule

The majority of human gastrointestinal stromal tumours (GIST) are driven by activating mutations in the proto-oncogene KIT, a tyrosine kinase receptor. Clinical treatment with imatinib targets the kinase domain of KIT, but tumour regrowth occurs as a result of the development of resistant mutations...

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Autori principali: Gunaratnam, Mekala, Beltran, Monica, Galesa, Katja, Haider, Shozeb M., Reszka, Anthony P., Cuenca, Francisco, Fletcher, Jonathan A., Neidle, Stephen
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900250/
https://ncbi.nlm.nih.gov/pubmed/19469547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900424a
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