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A “seleno-effect” differentiates the roles of redox active cysteine residues in Plasmodium falciparum thioredoxin reductase()

Here, we introduce the concept of the “seleno effect” in the study of oxidoreductases that catalyze thiol/disulfide exchange reactions. In these reactions, selenium can replace sulfur as a nucleophile, electrophile, or leaving group, and the resulting change in rate (the seleno effect) is defined as...

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Bibliografiske detaljer
Udgivet i:Biochemistry
Main Authors: O’Keefe, John P., Dustin, Christopher M., Barber, Drew, Snider, Gregg W., Hondal, Robert J.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866731/
https://ncbi.nlm.nih.gov/pubmed/29485860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00004
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