Resolution of oxidative stress by thioredoxin reductase: Cysteine versus selenocysteine

Thioredoxin reductase (TR) catalyzes the reduction of thioredoxin (TRX), which in turn reduces mammalian typical 2-Cys peroxiredoxins (PRXs 1–4), thiol peroxidases implicated in redox homeostasis and cell signaling. Typical 2-Cys PRXs are inactivated by hyperoxidation of the peroxidatic cysteine to...

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Detalhes bibliográficos
Main Authors: Cunniff, Brian, Snider, Gregg W., Fredette, Nicholas, Stumpff, Jason, Hondal, Robert J., Heintz, Nicholas H.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949094/
https://ncbi.nlm.nih.gov/pubmed/24624337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2014.01.021
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