Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) outgrowth depends on signals from the microenvironment. We have previously found that in vitro reconstitution of this microenvironment induces specific variant isoforms of the adhesion molecule CD44, which confer human CLL with high affinity to hyaluronan (HA). Her...

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Publicado en:Blood
Autores principales: Gutjahr, Julia C., Szenes, Eva, Tschech, Lisa, Asslaber, Daniela, Schlederer, Michaela, Roos, Simone, Yu, Xiaobing, Girbl, Tamara, Sternberg, Christina, Egle, Alexander, Aberger, Fritz, Alon, Ronen, Kenner, Lukas, Greil, Richard, Orian-Rousseau, Veronique, Hartmann, Tanja N.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2018
Materias:
Lymphoid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865232/
https://ncbi.nlm.nih.gov/pubmed/29352038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-08-802462
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