Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) outgrowth depends on signals from the microenvironment. We have previously found that in vitro reconstitution of this microenvironment induces specific variant isoforms of the adhesion molecule CD44, which confer human CLL with high affinity to hyaluronan (HA). Her...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Gutjahr, Julia C., Szenes, Eva, Tschech, Lisa, Asslaber, Daniela, Schlederer, Michaela, Roos, Simone, Yu, Xiaobing, Girbl, Tamara, Sternberg, Christina, Egle, Alexander, Aberger, Fritz, Alon, Ronen, Kenner, Lukas, Greil, Richard, Orian-Rousseau, Veronique, Hartmann, Tanja N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865232/
https://ncbi.nlm.nih.gov/pubmed/29352038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-08-802462
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