CD44 engagement enhances acute myeloid leukemia cell adhesion to the bone marrow microenvironment by increasing VLA-4 avidity

Adhesive properties of leukemia cells shape the degree of organ infiltration and the extent of leukocytosis. CD44 and the integrin VLA-4, a CD49d/CD29 heterodimer, are important factors in progenitor cell adhesion in bone marrow. Here, we report their cooperation in acute myeloid leukemia (AML) by a...

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Publié dans:Haematologica
Auteurs principaux: Gutjahr, Julia C., Bayer, Elisabeth, Yu, Xiaobing, Laufer, Julia M., Höpner, Jan P., Tesanovic, Suzana, Härzschel, Andrea, Auer, Georg, Rieß, Tanja, Salmhofer, Astrid, Szenes, Eva, Haslauer, Theresa, Durand-Onayli, Valerie, Ramspacher, Andrea, Pennisi, Sandra P., Artinger, Marc, Zaborsky, Nadja, Chigaev, Alexandre, Aberger, Fritz, Neureiter, Daniel, Pleyer, Lisa, Legler, Daniel F., Orian-Rousseau, Veronique, Greil, Richard, Hartmann, Tanja N.
Format: Artigo
Langue:Inglês
Publié: Fondazione Ferrata Storti 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8327716/
https://ncbi.nlm.nih.gov/pubmed/32616529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.231944
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