Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) outgrowth depends on signals from the microenvironment. We have previously found that in vitro reconstitution of this microenvironment induces specific variant isoforms of the adhesion molecule CD44, which confer human CLL with high affinity to hyaluronan (HA). Her...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Blood
Päätekijät: Gutjahr, Julia C., Szenes, Eva, Tschech, Lisa, Asslaber, Daniela, Schlederer, Michaela, Roos, Simone, Yu, Xiaobing, Girbl, Tamara, Sternberg, Christina, Egle, Alexander, Aberger, Fritz, Alon, Ronen, Kenner, Lukas, Greil, Richard, Orian-Rousseau, Veronique, Hartmann, Tanja N.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2018
Aiheet:
Lymphoid Neoplasia
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865232/
https://ncbi.nlm.nih.gov/pubmed/29352038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-08-802462
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