Hippo signaling suppresses cell ploidy and tumorigenesis through Skp2

Polyploidy can lead to aneuploidy and tumorigenesis. Here, we report that the Hippo pathway effector Yap promotes the diploid-polyploid conversion and polyploid cell growth through the Akt-Skp2 axis. Yap strongly induces the acetyltransferase p300-mediated acetylation of the E3 ligase Skp2 via Akt s...

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Publicado no:Cancer Cell
Main Authors: Zhang, Shihao, Chen, Qinghua, Liu, Qingxu, Li, Yuxi, Sun, Xiufeng, Hong, Lixin, Ji, Suyuan, Liu, Chengyan, Geng, Jing, Zhang, Weiji, Lu, Zhonglei, Yin, Zhen-Yu, Zeng, Yuanyuan, Lin, Kwang-Huei, Wu, Qiao, Li, Qiyuan, Nakayama, Keiko, Nakayama, Keiich I., Deng, Xianming, Johnson, Randy L., Zhu, Liang, Gao, Daming, Chen, Lanfen, Zhou, Dawang
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5863541/
https://ncbi.nlm.nih.gov/pubmed/28486106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.04.004
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