Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences

Etoposide and other topoisomerase II-targeted drugs are important anticancer therapeutics. Unfortunately, the safe usage of these agents is limited by their indiscriminate induction of topoisomerase II-mediated DNA cleavage throughout the genome and by a lack of specificity toward cancer cells. Ther...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Autores principales: Infante Lara, Lorena, Fenner, Sabine, Ratcliffe, Steven, Isidro-Llobet, Albert, Hann, Michael, Bax, Ben, Osheroff, Neil
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5861436/
https://ncbi.nlm.nih.gov/pubmed/29447373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky072
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