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DNA-binding landscape of IRF3, IRF5 and IRF7 dimers: implications for dimer-specific gene regulation

Transcription factors IRF3, IRF5 and IRF7 (IRF3/5/7) have overlapping, yet distinct, roles in the mammalian response to pathogens. To examine the role that DNA-binding specificity plays in delineating IRF3/5/7-specific gene regulation we used protein-binding microarrays (PBMs) to characterize the DN...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Andrilenas, Kellen K, Ramlall, Vijendra, Kurland, Jesse, Leung, Brandon, Harbaugh, Allen G, Siggers, Trevor
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2018
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5861432/
https://ncbi.nlm.nih.gov/pubmed/29361124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky002
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