Characterization of distinct molecular interactions responsible for IRF3 and IRF7 phosphorylation and subsequent dimerization

IRF3 and IRF7 are critical transcription factors in the innate immune response. Their activation is controlled by phosphorylation events, leading to the formation of homodimers that are transcriptionally active. Phosphorylation occurs when IRF3 is recruited to adaptor proteins via a positively charg...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Dalskov, Louise, Narita, Ryo, Andersen, Line L, Jensen, Nanna, Assil, Sonia, Kristensen, Kennith H, Mikkelsen, Jacob G, Fujita, Takashi, Mogensen, Trine H, Paludan, Søren R, Hartmann, Rune
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7672473/
https://ncbi.nlm.nih.gov/pubmed/33205822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa873
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