Functional IRF3 deficiency in a patient with herpes simplex encephalitis

Herpes simplex encephalitis (HSE) in children has previously been linked to defects in type I interferon (IFN) production downstream of Toll-like receptor 3. Here, we describe a novel genetic etiology of HSE by identifying a heterozygous loss-of-function mutation in the IFN regulatory factor 3 (IRF3...

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Publicat a:J Exp Med
Autors principals: Andersen, Line Lykke, Mørk, Nanna, Reinert, Line S., Kofod-Olsen, Emil, Narita, Ryo, Jørgensen, Sofie E., Skipper, Kristian A., Höning, Klara, Gad, Hans Henrik, Østergaard, Lars, Ørntoft, Torben F., Hornung, Veit, Paludan, Søren R., Mikkelsen, Jacob Giehm, Fujita, Takashi, Christiansen, Mette, Hartmann, Rune, Mogensen, Trine H.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2015
Matèries:
Brief Definitive Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548062/
https://ncbi.nlm.nih.gov/pubmed/26216125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20142274
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