Functional IRF3 deficiency in a patient with herpes simplex encephalitis

Herpes simplex encephalitis (HSE) in children has previously been linked to defects in type I interferon (IFN) production downstream of Toll-like receptor 3. Here, we describe a novel genetic etiology of HSE by identifying a heterozygous loss-of-function mutation in the IFN regulatory factor 3 (IRF3...

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Bibliografske podrobnosti
izdano v:J Exp Med
Main Authors: Andersen, Line Lykke, Mørk, Nanna, Reinert, Line S., Kofod-Olsen, Emil, Narita, Ryo, Jørgensen, Sofie E., Skipper, Kristian A., Höning, Klara, Gad, Hans Henrik, Østergaard, Lars, Ørntoft, Torben F., Hornung, Veit, Paludan, Søren R., Mikkelsen, Jacob Giehm, Fujita, Takashi, Christiansen, Mette, Hartmann, Rune, Mogensen, Trine H.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2015
Teme:
Brief Definitive Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548062/
https://ncbi.nlm.nih.gov/pubmed/26216125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20142274
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