Functional IRF3 deficiency in a patient with herpes simplex encephalitis

Herpes simplex encephalitis (HSE) in children has previously been linked to defects in type I interferon (IFN) production downstream of Toll-like receptor 3. Here, we describe a novel genetic etiology of HSE by identifying a heterozygous loss-of-function mutation in the IFN regulatory factor 3 (IRF3...

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Bibliografiset tiedot
Julkaisussa:J Exp Med
Päätekijät: Andersen, Line Lykke, Mørk, Nanna, Reinert, Line S., Kofod-Olsen, Emil, Narita, Ryo, Jørgensen, Sofie E., Skipper, Kristian A., Höning, Klara, Gad, Hans Henrik, Østergaard, Lars, Ørntoft, Torben F., Hornung, Veit, Paludan, Søren R., Mikkelsen, Jacob Giehm, Fujita, Takashi, Christiansen, Mette, Hartmann, Rune, Mogensen, Trine H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Rockefeller University Press 2015
Aiheet:
Brief Definitive Report
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548062/
https://ncbi.nlm.nih.gov/pubmed/26216125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20142274
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