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CRISPR/Cas9-mediated modulation of splicing efficiency reveals short splicing isoform of Xist RNA is sufficient to induce X-chromosome inactivation

Alternative splicing of mRNA precursors results in multiple protein variants from a single gene and is critical for diverse cellular processes and development. Xist encodes a long noncoding RNA which is a central player to induce X-chromosome inactivation in female mammals and has two major splicing...

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書目詳細資料
發表在:Nucleic Acids Res
Main Authors: Yue, Minghui, Ogawa, Yuya
格式: Artigo
語言:Inglês
出版: Oxford University Press 2018
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5861412/
https://ncbi.nlm.nih.gov/pubmed/29237010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1227
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