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Xist Exon 7 Contributes to the Stable Localization of Xist RNA on the Inactive X-Chromosome

To equalize X-linked gene dosage between the sexes in mammalian females, Xist RNA inactivates one of the two X-chromosomes. Here, we report the crucial function of Xist exon 7 in X-inactivation. Xist exon 7 is the second-largest exon with a well-conserved repeat E in eutherian mammals, but its role...

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Bibliografiske detaljer
Udgivet i:PLoS Genet
Main Authors: Yamada, Norishige, Hasegawa, Yuko, Yue, Minghui, Hamada, Tomofumi, Nakagawa, Shinichi, Ogawa, Yuya
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526699/
https://ncbi.nlm.nih.gov/pubmed/26244333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005430
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