METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m(6)A Modification

N(6)-methyladenosine (m(6)A), the most prevalent internal modification in eukaryotic messenger RNAs (mRNAs), plays critical roles in many bioprocesses. However, its functions in normal and malignant hematopoiesis remain elusive. Here we report METTL14, a key component of the m(6)A methyltransferase...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Cell Stem Cell
Hoofdauteurs: Weng, Hengyou, Huang, Huilin, Wu, Huizhe, Qin, Xi, Zhao, Boxuan Simen, Dong, Lei, Shi, Hailing, Skibbe, Jennifer, Shen, Chao, Hu, Chao, Sheng, Yue, Wang, Yungui, Wunderlich, Mark, Zhang, Bin, Dore, Louis C, Su, Rui, Deng, Xiaolan, Ferchen, Kyle, Li, Chenying, Sun, Miao, Lu, Zhike, Jiang, Xi, Marcucci, Guido, Mulloy, James, Yang, Jianhua, Qian, Zhijian, Wei, Minjie, He, Chuan, Chen, Jianjun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5860916/
https://ncbi.nlm.nih.gov/pubmed/29290617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.11.016
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items