METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m(6)A Modification

N(6)-methyladenosine (m(6)A), the most prevalent internal modification in eukaryotic messenger RNAs (mRNAs), plays critical roles in many bioprocesses. However, its functions in normal and malignant hematopoiesis remain elusive. Here we report METTL14, a key component of the m(6)A methyltransferase...

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Publicado no:Cell Stem Cell
Main Authors: Weng, Hengyou, Huang, Huilin, Wu, Huizhe, Qin, Xi, Zhao, Boxuan Simen, Dong, Lei, Shi, Hailing, Skibbe, Jennifer, Shen, Chao, Hu, Chao, Sheng, Yue, Wang, Yungui, Wunderlich, Mark, Zhang, Bin, Dore, Louis C, Su, Rui, Deng, Xiaolan, Ferchen, Kyle, Li, Chenying, Sun, Miao, Lu, Zhike, Jiang, Xi, Marcucci, Guido, Mulloy, James, Yang, Jianhua, Qian, Zhijian, Wei, Minjie, He, Chuan, Chen, Jianjun
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5860916/
https://ncbi.nlm.nih.gov/pubmed/29290617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.11.016
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