METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m(6)A Modification

N(6)-methyladenosine (m(6)A), the most prevalent internal modification in eukaryotic messenger RNAs (mRNAs), plays critical roles in many bioprocesses. However, its functions in normal and malignant hematopoiesis remain elusive. Here we report METTL14, a key component of the m(6)A methyltransferase...

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Detaylı Bibliyografya
Yayımlandı:Cell Stem Cell
Asıl Yazarlar: Weng, Hengyou, Huang, Huilin, Wu, Huizhe, Qin, Xi, Zhao, Boxuan Simen, Dong, Lei, Shi, Hailing, Skibbe, Jennifer, Shen, Chao, Hu, Chao, Sheng, Yue, Wang, Yungui, Wunderlich, Mark, Zhang, Bin, Dore, Louis C, Su, Rui, Deng, Xiaolan, Ferchen, Kyle, Li, Chenying, Sun, Miao, Lu, Zhike, Jiang, Xi, Marcucci, Guido, Mulloy, James, Yang, Jianhua, Qian, Zhijian, Wei, Minjie, He, Chuan, Chen, Jianjun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5860916/
https://ncbi.nlm.nih.gov/pubmed/29290617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.11.016
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