R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m(6)A/MYC/CEBPA Signaling

R-2-hydroxyglutarate (R-2HG), produced at high levels by mutant isocitrate dehydrogenase 1/2 (IDH1/2) enzymes, was reported as an oncometabolite. We show here that R-2HG also exerts a broad anti-leukemic activity in vitro and in vivo by inhibiting leukemia cell proliferation/viability, and promoting...

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Publicado no:Cell
Main Authors: Su, Rui, Dong, Lei, Li, Chenying, Nachtergaele, Sigrid, Wunderlich, Mark, Qing, Ying, Deng, Xiaolan, Wang, Yungui, Weng, Xiaocheng, Hu, Chao, Yu, Mengxia, Skibbe, Jennifer, Dai, Qing, Zou, Dongling, Wu, Tong, Yu, Kangkang, Weng, Hengyou, Huang, Huilin, Ferchen, Kyle, Qin, Xi, Zhang, Bin, Qi, Jun, Sasaki, Atsuo T., Plas, David, Bradner, James E., Wei, Minjie, Marcucci, Guido, Jiang, Xi, Mulloy, James, Jin, Jie, He, Chuan, Chen, Jianjun
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766423/
https://ncbi.nlm.nih.gov/pubmed/29249359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.11.031
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