Recognition of RNA N(6)-methyladenosine by IGF2BP Proteins Enhances mRNA Stability and Translation

N (6)-methyladenosine (m(6)A) is the most prevalent modification in eukaryotic messenger RNAs (mRNAs) and is interpreted by its readers, such as YTH domain-containing proteins, to regulate mRNA fate. Here we report the insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs; including IGF2BP1/2/...

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Publié dans:Nat Cell Biol
Auteurs principaux: Huang, Huilin, Weng, Hengyou, Sun, Wenju, Qin, Xi, Shi, Hailing, Wu, Huizhe, Zhao, Boxuan Simen, Mesquita, Ana, Liu, Chang, Yuan, Celvie L., Hu, Yueh-Chiang, Hüttelmaier, Stefan, Skibbe, Jennifer R., Su, Rui, Deng, Xiaolan, Dong, Lei, Sun, Miao, Li, Chenying, Nachtergaele, Sigrid, Wang, Yungui, Hu, Chao, Ferchen, Kyle, Greis, Kenneth D., Jiang, Xi, Wei, Minjie, Qu, Lianghu, Guan, Jun-Lin, He, Chuan, Yang, Jianhua, Chen, Jianjun
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826585/
https://ncbi.nlm.nih.gov/pubmed/29476152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0045-z
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