Recognition of RNA N(6)-methyladenosine by IGF2BP Proteins Enhances mRNA Stability and Translation

N (6)-methyladenosine (m(6)A) is the most prevalent modification in eukaryotic messenger RNAs (mRNAs) and is interpreted by its readers, such as YTH domain-containing proteins, to regulate mRNA fate. Here we report the insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs; including IGF2BP1/2/...

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Publicado no:Nat Cell Biol
Main Authors: Huang, Huilin, Weng, Hengyou, Sun, Wenju, Qin, Xi, Shi, Hailing, Wu, Huizhe, Zhao, Boxuan Simen, Mesquita, Ana, Liu, Chang, Yuan, Celvie L., Hu, Yueh-Chiang, Hüttelmaier, Stefan, Skibbe, Jennifer R., Su, Rui, Deng, Xiaolan, Dong, Lei, Sun, Miao, Li, Chenying, Nachtergaele, Sigrid, Wang, Yungui, Hu, Chao, Ferchen, Kyle, Greis, Kenneth D., Jiang, Xi, Wei, Minjie, Qu, Lianghu, Guan, Jun-Lin, He, Chuan, Yang, Jianhua, Chen, Jianjun
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826585/
https://ncbi.nlm.nih.gov/pubmed/29476152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0045-z
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