N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency

N(6)-methyladenosine (m(6)A) is the most abundant internal modification in mammalian mRNA. This modification is reversible and non-stoichiometric and adds another layer to the dynamic control of mRNA metabolism. The stability of m(6)A-modified mRNA is regulated by an m(6)A reader protein, human YTHD...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Wang, Xiao, Zhao, Boxuan Simen, Roundtree, Ian A., Lu, Zhike, Han, Dali, Ma, Honghui, Weng, Xiaocheng, Chen, Kai, Shi, Hailing, He, Chuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825696/
https://ncbi.nlm.nih.gov/pubmed/26046440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.05.014
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