Protein Kinase G Activation Reverses Oxidative Stress and Restores Osteoblast Function and Bone Formation in Male Mice With Type 1 Diabetes

Bone loss and fractures are underrecognized complications of type 1 diabetes and are primarily due to impaired bone formation by osteoblasts. The mechanisms leading to osteoblast dysfunction in diabetes are incompletely understood, but insulin deficiency, poor glycemic control, and hyperglycemia-ind...

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Bibliografiske detaljer
Udgivet i:Diabetes
Main Authors: Kalyanaraman, Hema, Schwaerzer, Gerburg, Ramdani, Ghania, Castillo, Francine, Scott, Brian T., Dillmann, Wolfgang, Sah, Robert L., Casteel, Darren E., Pilz, Renate B.
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2018
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5860855/
https://ncbi.nlm.nih.gov/pubmed/29301852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-0965
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