Protein Kinase G and Focal Adhesion Kinase Converge on Src/Akt/β-Catenin Signaling Module in Osteoblast Mechanotransduction

Mechanical loading of bone induces interstitial fluid flow, leading to fluid shear stress (FSS) of osteoblasts. FSS rapidly increases the intracellular calcium concentration ([Ca(2+)]) and nitric oxide (NO) synthesis in osteoblasts and activates the protein kinase Akt. Activated Akt stimulates osteo...

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Bibliographische Detailangaben
Hauptverfasser: Rangaswami, Hema, Schwappacher, Raphaela, Tran, Trish, Chan, Geraldine C., Zhuang, Shunhui, Boss, Gerry R., Pilz, Renate B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375572/
https://ncbi.nlm.nih.gov/pubmed/22563076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.347245
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