3′-epi-12β-hydroxyfroside, a new cardenolide, induces cytoprotective autophagy via blocking the Hsp90/Akt/mTOR axis in lung cancer cells

Rationale: Cardenolides have potential as anticancer drugs. 3′-epi-12β-hydroxyfroside (HyFS) is a new cardenolide structure isolated by our research group, but its molecular mechanisms remain poorly understood. This study investigates the relationship between its antitumor activities and autophagy i...

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Bibliografiske detaljer
Udgivet i:Theranostics
Main Authors: Sun, Yan, Huang, Yong-Hao, Huang, Feng-Ying, Mei, Wen-Li, Liu, Quan, Wang, Cai-Chun, Lin, Ying-Ying, Huang, Canhua, Li, Yue-Nan, Dai, Hao-Fu, Tan, Guang-Hong
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5858516/
https://ncbi.nlm.nih.gov/pubmed/29556372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.23304
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