Elevated expression of HSP90 and the antitumor effect of an HSP90 inhibitor via inactivation of the Akt/mTOR pathway in undifferentiated pleomorphic sarcoma

BACKGROUND: Undifferentiated pleomorphic sarcoma (UPS) is a heterogeneous tumor group, and little is known about molecular target therapy for UPS. Heat shock protein 90 (HSP90) is an expressed chaperone that refolds certain denatured proteins under stress conditions. One of these proteins is Akt. Th...

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Dades bibliogràfiques
Publicat a:BMC Cancer
Autors principals: Bekki, Hirofumi, Kohashi, Kenichi, Maekawa, Akira, Yamada, Yuichi, Yamamoto, Hidetaka, Harimaya, Katsumi, Hakozaki, Michiyuki, Nabeshima, Kazuki, Iwamoto, Yukihide, Oda, Yoshinao
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623920/
https://ncbi.nlm.nih.gov/pubmed/26502919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1830-8
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