Elevated expression of HSP90 and the antitumor effect of an HSP90 inhibitor via inactivation of the Akt/mTOR pathway in undifferentiated pleomorphic sarcoma

BACKGROUND: Undifferentiated pleomorphic sarcoma (UPS) is a heterogeneous tumor group, and little is known about molecular target therapy for UPS. Heat shock protein 90 (HSP90) is an expressed chaperone that refolds certain denatured proteins under stress conditions. One of these proteins is Akt. Th...

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Vydáno v:BMC Cancer
Hlavní autoři: Bekki, Hirofumi, Kohashi, Kenichi, Maekawa, Akira, Yamada, Yuichi, Yamamoto, Hidetaka, Harimaya, Katsumi, Hakozaki, Michiyuki, Nabeshima, Kazuki, Iwamoto, Yukihide, Oda, Yoshinao
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623920/
https://ncbi.nlm.nih.gov/pubmed/26502919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1830-8
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