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Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes
We reported previously that the stability of all mammalian phosphatidylinositol 3-kinase-related protein kinases (PIKKs) depends on their interaction with Tel2, the ortholog of yeast Tel2 and Caenorhabditis elegans Clk-2. Here we provide evidence that Tel2 acts with Hsp90 in the maturation of PIKK c...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2939364/ https://ncbi.nlm.nih.gov/pubmed/20801936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1956410 |
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