PI3K-independent mTOR activation promotes lapatinib resistance and IAP expression that can be effectively reversed by mTOR and Hsp90 inhibition

Although HER2 targeted therapies have substantially improved outcomes in HER2 overexpressing (HER2+) breast cancer, resistance to these therapies remains a clinical challenge. To better understand the mechanisms of resistance to lapatinib, a HER2 and EGFR dual kinase inhibitor, we treated HER2+ brea...

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Vydáno v:Cancer Biol Ther
Hlavní autoři: Brady, Samuel W, Zhang, Jian, Tsai, Ming-Horng, Yu, Dihua
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623386/
https://ncbi.nlm.nih.gov/pubmed/25692408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2014.1002693
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