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PI3K-independent mTOR activation promotes lapatinib resistance and IAP expression that can be effectively reversed by mTOR and Hsp90 inhibition

Although HER2 targeted therapies have substantially improved outcomes in HER2 overexpressing (HER2+) breast cancer, resistance to these therapies remains a clinical challenge. To better understand the mechanisms of resistance to lapatinib, a HER2 and EGFR dual kinase inhibitor, we treated HER2+ brea...

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Bibliografski detalji
Izdano u:Cancer Biol Ther
Glavni autori: Brady, Samuel W, Zhang, Jian, Tsai, Ming-Horng, Yu, Dihua
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623386/
https://ncbi.nlm.nih.gov/pubmed/25692408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2014.1002693
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