Inhibition of Hsp90 suppresses PI3K/AKT/mTOR signaling and has antitumor activity in Burkitt lymphoma

Heat shock protein 90 (Hsp90) is a molecular chaperone that protects proteins, including oncogenic signaling complexes, from proteolytic degradation. PU-H71 is a next-generation Hsp90 inhibitor that preferentially targets the functionally distinct pool of Hsp90 present in tumor cells. Tumors that ar...

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Vydáno v:Mol Cancer Ther
Hlavní autoři: Giulino-Roth, Lisa, van Besien, Herman J., Dalton, Tanner, Totonchy, Jennifer E., Rodina, Anna, Taldone, Tony, Bolaender, Alexander, Erdjument-Bromage, Hediye, Sadek, Jouliana, Chadburn, Amy, Barth, Matthew J., Dela Cruz, Filemon S., Rainey, Allison, Kung, Andrew L., Chiosis, Gabriela, Cesarman, Ethel
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587381/
https://ncbi.nlm.nih.gov/pubmed/28619753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0848
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