Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies

PU-H71 is a purine-scaffold Hsp90 inhibitor that, in contrast to other Hsp90 inhibitors, displays unique selectivity for binding the fraction of Hsp90 that is preferentially associated with oncogenic client proteins and enriched in tumor cells (teHsp90). This property allows PU-H71 to potently suppr...

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Detalhes bibliográficos
Main Authors: Nayar, Utthara, Lu, Pin, Goldstein, Rebecca L., Vider, Jelena, Ballon, Gianna, Rodina, Anna, Taldone, Tony, Erdjument-Bromage, Hediye, Chomet, Max, Blasberg, Ronald, Melnick, Ari, Cerchietti, Leandro, Chiosis, Gabriela, Wang, Y. Lynn, Cesarman, Ethel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798998/
https://ncbi.nlm.nih.gov/pubmed/23943653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-01-479972
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