Chronic exposure to tumor necrosis factor alpha induces retinal pigment epithelium cell dedifferentiation

BACKGROUND: The retinal pigment epithelium (RPE) is a monolayer of pigmented cells with important barrier and immuno-suppressive functions in the eye. We have previously shown that acute stimulation of RPE cells by tumor necrosis factor alpha (TNFα) downregulates the expression of OTX2 (Orthodenticl...

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Detalles Bibliográficos
Publicado en:J Neuroinflammation
Main Authors: Touhami, Sara, Beguier, Fanny, Augustin, Sébastien, Charles-Messance, Hugo, Vignaud, Lucile, Nandrot, Emeline F., Reichman, Sacha, Forster, Valérie, Mathis, Thibaud, Sahel, José-Alain, Bodaghi, Bahram, Guillonneau, Xavier, Sennlaub, Florian
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2018
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857126/
https://ncbi.nlm.nih.gov/pubmed/29548329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1106-8
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