mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice

Retinal pigment epithelial (RPE) cell dysfunction plays a central role in various retinal degenerative diseases, but knowledge is limited regarding the pathways responsible for adult RPE stress responses in vivo. RPE mitochondrial dysfunction has been implicated in the pathogenesis of several forms...

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Detalhes bibliográficos
Main Authors: Zhao, Chen, Yasumura, Douglas, Li, Xiyan, Matthes, Michael, Lloyd, Marcia, Nielsen, Gregory, Ahern, Kelly, Snyder, Michael, Bok, Dean, Dunaief, Joshua L., LaVail, Matthew M., Vollrath, Douglas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3007156/
https://ncbi.nlm.nih.gov/pubmed/21135502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44303
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