mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice

Retinal pigment epithelial (RPE) cell dysfunction plays a central role in various retinal degenerative diseases, but knowledge is limited regarding the pathways responsible for adult RPE stress responses in vivo. RPE mitochondrial dysfunction has been implicated in the pathogenesis of several forms...

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Bibliografski detalji
Glavni autori: Zhao, Chen, Yasumura, Douglas, Li, Xiyan, Matthes, Michael, Lloyd, Marcia, Nielsen, Gregory, Ahern, Kelly, Snyder, Michael, Bok, Dean, Dunaief, Joshua L., LaVail, Matthew M., Vollrath, Douglas
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2010
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3007156/
https://ncbi.nlm.nih.gov/pubmed/21135502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44303
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