Activated monocytes resist elimination by retinal pigment epithelium and downregulate their OTX2 expression via TNF‐α

Orthodenticle homeobox 2 (OTX2) controls essential, homeostatic retinal pigment epithelial (RPE) genes in the adult. Using cocultures of human CD14(+) blood monocytes (Mos) and primary porcine RPE cells and a fully humanized system using human‐induced pluripotent stem cell‐derived RPE cells, we show...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Mathis, Thibaud, Housset, Michael, Eandi, Chiara, Beguier, Fanny, Touhami, Sara, Reichman, Sacha, Augustin, Sebastien, Gondouin, Pauline, Sahel, José‐Alain, Kodjikian, Laurent, Goureau, Olivier, Guillonneau, Xavier, Sennlaub, Florian
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5242302/
https://ncbi.nlm.nih.gov/pubmed/27660103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12540
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