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Otx2-Genetically Modified Retinal Pigment Epithelial Cells Rescue Photoreceptors after Transplantation

Inherited retinal degenerations are blinding diseases characterized by the loss of photoreceptors. Their extreme genetic heterogeneity complicates treatment by gene therapy. This has motivated broader strategies for transplantation of healthy retinal pigmented epithelium to protect photoreceptors in...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Kole, Christo, Klipfel, Laurence, Yang, Ying, Ferracane, Vanessa, Blond, Frederic, Reichman, Sacha, Millet-Puel, Géraldine, Clérin, Emmanuelle, Aït-Ali, Najate, Pagan, Delphine, Camara, Hawa, Delyfer, Marie-Noëlle, Nandrot, Emeline F., Sahel, Jose-Alain, Goureau, Olivier, Léveillard, Thierry
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762984/
https://ncbi.nlm.nih.gov/pubmed/28988713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.09.007
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