LKB1, Salt-Inducible Kinases, and MEF2C are linked dependencies in acute myeloid leukemia

The lineage-specific transcription factor (TF) MEF2C is often deregulated in leukemia. However, strategies to target this TF have yet to be identified. Here we used a domain-focused CRISPR screen to reveal an essential role for LKB1 and its Salt-Inducible Kinase effectors (SIK3, in a partially redun...

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Vydáno v:Mol Cell
Hlavní autoři: Tarumoto, Yusuke, Lu, Bin, Somerville, Tim D. D., Huang, Yu-Han, Milazzo, Joseph P., Wu, Xiaoli S., Klingbeil, Olaf, El Demerdash, Osama, Shi, Junwei, Vakoc, Christopher R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856641/
https://ncbi.nlm.nih.gov/pubmed/29526696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.02.011
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