Inhibiting Skp2 E3 Ligase Suppresses Bleomycin-Induced Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with poor prognosis and no curative therapies. SCF-Skp2 E3 ligase is a target for cancer therapy, but there have been no reports about Skp2 as a target for IPF. Here we demonstrate that Skp2 is a promising therapeutic target for IPF. We ex...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Mikamo, Masashi, Kitagawa, Kyoko, Sakai, Satoshi, Uchida, Chiharu, Ohhata, Tatsuya, Nishimoto, Koji, Niida, Hiroyuki, Suzuki, Sayuri, Nakayama, Keiichi I., Inui, Naoki, Suda, Takafumi, Kitagawa, Masatoshi
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5855696/
https://ncbi.nlm.nih.gov/pubmed/29415439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19020474
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