Regulation of GATA-binding Protein 2 Levels via Ubiquitin-dependent Degradation by Fbw7: INVOLVEMENT OF CYCLIN B-CYCLIN-DEPENDENT KINASE 1-MEDIATED PHOSPHORYLATION OF THR(176) IN GATA-BINDING PROTEIN 2

A GATA family transcription factor, GATA-binding protein 2 (GATA2), participates in cell growth and differentiation of various cells, such as hematopoietic stem cells. Although its expression level is controlled by transcriptional induction and proteolytic degradation, the responsible E3 ligase has...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Nakajima, Tomomi, Kitagawa, Kyoko, Ohhata, Tatsuya, Sakai, Satoshi, Uchida, Chiharu, Shibata, Kiyoshi, Minegishi, Naoko, Yumimoto, Kanae, Nakayama, Keiichi I., Masumoto, Kazuma, Katou, Fuminori, Niida, Hiroyuki, Kitagawa, Masatoshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Protein Synthesis and Degradation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4400347/
https://ncbi.nlm.nih.gov/pubmed/25670854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.613018
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