Regulation of GATA-binding Protein 2 Levels via Ubiquitin-dependent Degradation by Fbw7: INVOLVEMENT OF CYCLIN B-CYCLIN-DEPENDENT KINASE 1-MEDIATED PHOSPHORYLATION OF THR(176) IN GATA-BINDING PROTEIN 2

A GATA family transcription factor, GATA-binding protein 2 (GATA2), participates in cell growth and differentiation of various cells, such as hematopoietic stem cells. Although its expression level is controlled by transcriptional induction and proteolytic degradation, the responsible E3 ligase has...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Nakajima, Tomomi, Kitagawa, Kyoko, Ohhata, Tatsuya, Sakai, Satoshi, Uchida, Chiharu, Shibata, Kiyoshi, Minegishi, Naoko, Yumimoto, Kanae, Nakayama, Keiichi I., Masumoto, Kazuma, Katou, Fuminori, Niida, Hiroyuki, Kitagawa, Masatoshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4400347/
https://ncbi.nlm.nih.gov/pubmed/25670854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.613018
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