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Phosphorylation of the PCNA binding domain of the large subunit of replication factor C on Thr(506) by cyclin-dependent kinases regulates binding to PCNA

Replication factor C (RF-C) complex binds to DNA primers and loads PCNA onto DNA, thereby increasing the processivity of DNA polymerases. We have previously identified a distinct region, domain B, in the large subunit of human RF-C (RF-Cp145) which binds to PCNA. We show here that the functional int...

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Udgivet i:Nucleic Acids Res
Principais autores: Salles-Passador, Isabelle, Munshi, Anil, Cannella, Dominique, Pennaneach, Vincent, Koundrioukoff, Stephane, Jacquinod, Michel, Forest, Eric, Podust, Vladimir, Fotedar, Arun, Fotedar, Rati
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2003
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC212794/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12930972/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg692
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