Regulation of GATA-binding Protein 2 Levels via Ubiquitin-dependent Degradation by Fbw7: INVOLVEMENT OF CYCLIN B-CYCLIN-DEPENDENT KINASE 1-MEDIATED PHOSPHORYLATION OF THR(176) IN GATA-BINDING PROTEIN 2

A GATA family transcription factor, GATA-binding protein 2 (GATA2), participates in cell growth and differentiation of various cells, such as hematopoietic stem cells. Although its expression level is controlled by transcriptional induction and proteolytic degradation, the responsible E3 ligase has...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Nakajima, Tomomi, Kitagawa, Kyoko, Ohhata, Tatsuya, Sakai, Satoshi, Uchida, Chiharu, Shibata, Kiyoshi, Minegishi, Naoko, Yumimoto, Kanae, Nakayama, Keiichi I., Masumoto, Kazuma, Katou, Fuminori, Niida, Hiroyuki, Kitagawa, Masatoshi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Protein Synthesis and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4400347/
https://ncbi.nlm.nih.gov/pubmed/25670854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.613018
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